| http://purl.uniprot.org/citations/12376545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12376545 | http://www.w3.org/2000/01/rdf-schema#comment | "The presence of two protein-tyrosine phosphatase (PTP) domains is a striking feature in most transmembrane receptor PTPs (RPTPs). The generally inactive membrane-distal PTP domains (RPTP-D2s) bind and are proposed to regulate the membrane-proximal PTP domains (RPTP-D1s). We set out to characterize the interactions between RPTP-D1s and RPTP-D2s in vivo by co-immunoprecipitation of hemagglutinin-tagged fusion proteins encoding the transmembrane domain and RPTP-D1 and myc-tagged RPTP-D2. Seven RPTPs from four different subfamilies were used: RPTPalpha, RPTPepsilon, LAR, RPTPvarsigma, RPTPdelta, CD45, and RPTP(mu). We found that RPTP-D2s bound to RPTPs with different affinities. The presence of intrinsic RPTP-D2 altered the binding specificity toward other RPTP-D2s positively or negatively, depending on the identity of the RPTPs. Furthermore, the C terminus of RPTP-D2s and the "wedge" in RPTP-D1s played a central role in binding specificity. Finally, full-length RPTPalpha and LAR heterodimerized in an oxidative stress-dependent manner. Like RPTPalpha-D2, the LAR-D2 conformation was affected by oxidative stress, suggesting a common regulatory mechanism for RPTP complex formation. Taken together, interactions between RPTP-D1s and RPTP-D2s are a common but specific mechanism that is likely to be regulated. The RPTP-D2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs."xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205810200"xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/author | "den Hertog J."xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/author | "Blanchetot C."xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/author | "Overvoorde J."xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/author | "Tertoolen L.G."xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/pages | "47263-47269"xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/title | "Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases."xsd:string |
| http://purl.uniprot.org/citations/12376545 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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