| http://purl.uniprot.org/citations/12376595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12376595 | http://www.w3.org/2000/01/rdf-schema#comment | "The hairpin ribozyme catalyzes sequence-specific cleavage of RNA through transesterification of the scissile phosphate. Vanadate has previously been used as a transition state mimic of protein enzymes that catalyze the same reaction. Comparison of the 2.2 angstrom resolution structure of a vanadate-hairpin ribozyme complex with structures of precursor and product complexes reveals a rigid active site that makes more hydrogen bonds to the transition state than to the precursor or product. Because of the paucity of RNA functional groups capable of general acid-base or electrostatic catalysis, transition state stabilization is likely to be an important catalytic strategy for ribozymes."xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1076093"xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/author | "Ferre-D'Amare A.R."xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/author | "Rupert P.B."xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/author | "Sigurdsson S.T."xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/author | "Massey A.P."xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/pages | "1421-1424"xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/title | "Transition state stabilization by a catalytic RNA."xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://purl.uniprot.org/core/volume | "298"xsd:string |
| http://purl.uniprot.org/citations/12376595 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12376595 |
| http://purl.uniprot.org/citations/12376595 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12376595 |
| http://purl.uniprot.org/uniprot/#_P09012-mappedCitation-12376595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12376595 |
| http://purl.uniprot.org/uniprot/P09012 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12376595 |