| http://purl.uniprot.org/citations/12377127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12377127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12377127 | http://www.w3.org/2000/01/rdf-schema#comment | "FtsH is a cytoplasmic membrane-integrated, ATP-dependent metalloprotease, which processively degrades both cytoplasmic and membrane proteins in concert with unfolding. The FtsH protein is divided into the N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. We have determined the crystal structures of the Thermus thermophilus FtsH ATPase domain in the nucleotide-free and AMP-PNP- and ADP-bound states, in addition to the domain with the extra preceding segment. Combined with the mapping of the putative substrate binding region, these structures suggest that FtsH internally forms a hexameric ring structure, in which ATP binding could cause a conformational change to facilitate transport of substrates into the protease domain through the central pore."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0969-2126(02)00855-9"xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0969-2126(02)00855-9"xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Morikawa K."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Morikawa K."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Niwa H."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Niwa H."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Tsuchiya D."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Tsuchiya D."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Makyio H."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/author | "Makyio H."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/pages | "1415-1423"xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/pages | "1415-1423"xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/title | "Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/title | "Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8."xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/12377127 | http://purl.uniprot.org/core/volume | "10"xsd:string |