| http://purl.uniprot.org/citations/12377782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12377782 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rev-erb and retinoic acid-related orphan receptors (ROR) are two related families of orphan nuclear receptors that recognize similar response elements but have opposite effects on transcription. Recently, the Rev-erbalpha gene promoter has been characterized and shown to harbor a functional Rev-erbalpha-binding site known as Rev-DR2, responsible for negative feedback down-regulation of promoter activity by Rev-erbalpha itself. The present study aimed to investigate whether Rev-erbalpha gene expression is regulated by RORalpha. Gel shift analysis demonstrated that in vitro translated hRORalpha1 protein binds to the Rev-DR2 site, both as monomer and dimer. Chromatin immunoprecipitation assays demonstrated that binding of RORalpha to this site also occurred in vivo in human hepatoma HepG2 cells. The Rev-DR2 site was further shown to be functional as it conferred hRORalpha1 responsiveness to a heterologous promoter and to the natural human Rev-erbalpha gene promoter in these cells. Mutation of this site in the context of the natural Rev-erbalpha gene promoter abolished its activation by RORalpha, indicating that this site plays a key role in hRORalpha1 action. Finally, adenoviral overexpression of hRORalpha1 in HepG2 cells led to enhanced hRev-erbalpha mRNA accumulation, further confirming the physiological importance of RORalpha1 in the regulation of Rev-erbalpha expression."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m206215200"xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Duval C."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Fruchart J.C."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Staels B."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Raspe E."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Monte D."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Fontaine C."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Barbier O."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Duez H."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Fruchart J."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/author | "Mautino G."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/pages | "49275-49281"xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/title | "Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha."xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12377782 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12377782 |
| http://purl.uniprot.org/citations/12377782 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12377782 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG53-mappedCitation-12377782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12377782 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DFP5-mappedCitation-12377782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12377782 |
| http://purl.uniprot.org/uniprot/#_B6ZGS4-mappedCitation-12377782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12377782 |
| http://purl.uniprot.org/uniprot/#_B4DTC7-mappedCitation-12377782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12377782 |
| http://purl.uniprot.org/uniprot/#_F1D8S3-mappedCitation-12377782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12377782 |