| http://purl.uniprot.org/citations/12379450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12379450 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycogen synthase kinase-3 (GSK-3) is a highly conserved serine/threonine protein kinase that is involved in the signal transduction cascades of multiple cellular processes. GSK-3 has two isoforms, designated alpha and beta. GSK-3beta protein levels and GSK-3 enzyme activity have been reported to be reduced by over 40% in postmortem frontal cortex of schizophrenic patients. GSK-3 is also present in peripheral tissue such as lymphocytes. In this study we aimed to find whether the reduction in brain GSK-3beta measures is reflected in peripheral tissue of schizophrenic patients. Fresh lymphocytes from schizophrenic patients showed no difference in GSK-3 alpha and GSK-3beta mRNA levels, GSK-3beta protein levels, or total GSK-3 (alpha+beta) enzyme activity compared with findings in control subjects. In addition, lymphocyte-derived cell lines from schizophrenic patients did not differ in their GSK-3beta protein levels from levels in normal control subjects. The results rule out the use of lymphocyte GSK-3 as a marker for central GSK-3 abnormalities in schizophrenia."xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0165-1781(02)00191-9"xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/author | "Agam G."xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/author | "Bersudsky Y."xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/author | "Kozlovsky N."xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/author | "Nadri C."xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/name | "Psychiatry Res"xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/pages | "51-57"xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/title | "GSK-3 parameters in lymphocytes of schizophrenic patients."xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/12379450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12379450 |
| http://purl.uniprot.org/citations/12379450 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12379450 |
| http://purl.uniprot.org/uniprot/#_A0A3B3ITW1-mappedCitation-12379450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12379450 |
| http://purl.uniprot.org/uniprot/#_B5BUC0-mappedCitation-12379450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12379450 |
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