| http://purl.uniprot.org/citations/12381661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12381661 | http://www.w3.org/2000/01/rdf-schema#comment | "Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in one of two tumor suppressor genes, TSC1 and TSC2. Here, we show that absence of Drosophila Tsc1/2 leads to constitutive dS6K activation and inhibition of dPKB, the latter effect being relieved by loss of dS6K. In contrast, the dPTEN tumor suppressor, a negative effector of PI3K, has little effect on dS6K, but negatively regulates dPKB. More importantly, we demonstrate that reducing dS6K signaling rescues early larval lethality associated with loss of dTsc1/2 function, arguing that the S6K pathway is a promising target for the treatment of TSC."xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.239102"xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/author | "Hemmings-Mieszczak M."xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/author | "Radimerski T."xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/author | "Montagne J."xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/pages | "2627-2632"xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/title | "Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling."xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/12381661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12381661 |
| http://purl.uniprot.org/citations/12381661 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12381661 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KG15-mappedCitation-12381661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12381661 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4LIA3-mappedCitation-12381661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12381661 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4JD78-mappedCitation-12381661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12381661 |
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