| http://purl.uniprot.org/citations/12383518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12383518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12383518 | http://www.w3.org/2000/01/rdf-schema#comment | "Hemokinin-1 (HK-1) is a novel substance P (SP)-like peptide that is encoded by the preprotachykinin C (PPT-C) gene recently identified in mouse B cells and shown to be a potentially important regulator of B cell development (Nat. Immunol. 1 (2000) 392). We have now isolated and characterized the human and rat orthologs of PPT-C and examined activities of human and mouse HK-1 on the three tachykinin receptors, neurokinin-1-3 (NK1-3). The rat PPT-C polypeptide is highly homologous to mouse PPT-C and contains the same processing sites to generate predicted HK-1. The human PPT-C polypeptide is also homologous to mouse PPT-C, however, it contains two potential monobasic cleavage sites rather than a single dibasic cleavage site at the amino-terminal end of the predicted HK-1 peptide. Thus, human PPT-C has the potential to generate full length predicted HK-1 as well as a truncated version (HK-1(4-11)). Polymerase chain reaction analysis revealed that both human and mouse PPT-C were expressed in a variety of tissues with strong signals detected in the skin of both species and in the mouse brain. Binding and functional analysis indicated that human and mouse HK-1 peptides were nearly identical to SP in their overall activity profile on the three NK receptors with the most potent affinity for the NK1 receptor. The results indicate that PPT-C encodes another high affinity ligand of the NK1 receptor which may play an important role in mediating some of the physiological roles previously assigned to the NK1 receptor."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(02)00861-2"xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(02)00861-2"xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Cascieri M.A."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Cascieri M.A."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Cunningham B.R."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Cunningham B.R."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Austin C.P."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Austin C.P."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Clements M.K."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Clements M.K."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Chicchi G.G."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Chicchi G.G."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Kurtz M.M."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/author | "Kurtz M.M."xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/12383518 | http://purl.uniprot.org/core/name | "Gene"xsd:string |