http://purl.uniprot.org/citations/12384689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12384689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12384689 | http://www.w3.org/2000/01/rdf-schema#comment | "Brain-derived neurotrophic factor (BDNF) and other neurotrophins are essential for normal brain function. Many types of neurons in the central nervous system are excited by BDNF or neurotrophin-4/5, an action that has recently been implicated in synaptic plasticity. The mechanisms involved in this transmitter-like action of neurotrophins remains unclear. Here, by screening candidate genes with an antisense messenger RNA expression approach and by co-expressing the receptor tyrosine kinase TrkB and various sodium channels, we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation. These results establish the molecular basis of neurotrophin-evoked depolarization and reveal a mechanism of ligand-mediated sodium channel activation."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01085"xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01085"xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/author | "Blum R."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/author | "Blum R."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/author | "Kafitz K.W."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/author | "Kafitz K.W."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/author | "Konnerth A."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/author | "Konnerth A."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/pages | "687-693"xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/pages | "687-693"xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/title | "Neurotrophin-evoked depolarization requires the sodium channel Nav1.9."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/title | "Neurotrophin-evoked depolarization requires the sodium channel Nav1.9."xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/volume | "419"xsd:string |
http://purl.uniprot.org/citations/12384689 | http://purl.uniprot.org/core/volume | "419"xsd:string |
http://purl.uniprot.org/citations/12384689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12384689 |
http://purl.uniprot.org/citations/12384689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12384689 |
http://purl.uniprot.org/citations/12384689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12384689 |
http://purl.uniprot.org/citations/12384689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12384689 |