| http://purl.uniprot.org/citations/12387735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12387735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12387735 | http://www.w3.org/2000/01/rdf-schema#comment | "P-selectin glycoprotein ligand 1 (PSGL-1) is a leukocyte adhesion molecule involved in cell tether and rolling on activated endothelium. Our work shows that PSGL-1 associates with Syk. This association is mediated by the actin-linking proteins moesin and ezrin, which directly interact with Syk in an ITAM-dependent manner. PSGL-1 engagement induces tyrosine phosphorylation of Syk and SRE-dependent transcriptional activity. Treatment of cells with the Syk inhibitor piceatannol and overexpression of either a Syk dead kinase mutant or an ITAM-mutated moesin abrogated PSGL-1-induced transcriptional activation. These data unveil a new functional role for the ERMs (ezrin/radixin/moesin) as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases and show that PSGL-1 is a signaling molecule in leukocytes."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00420-x"xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00420-x"xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Rodriguez A."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Rodriguez A."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Urzainqui A."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Urzainqui A."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Vazquez J."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Vazquez J."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Luque A."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Luque A."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Corbi A.L."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Corbi A.L."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Deckert M."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Deckert M."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Sanchez-Madrid F."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Sanchez-Madrid F."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Viedma F."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Viedma F."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Yanez-Mo M."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Yanez-Mo M."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Alonso-Lebrero J.L."xsd:string |
| http://purl.uniprot.org/citations/12387735 | http://purl.uniprot.org/core/author | "Alonso-Lebrero J.L."xsd:string |