| http://purl.uniprot.org/citations/12388077 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12388077 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, development of a caveolin-1-deficient (Cav-1 null) mouse model has allowed the detailed analysis of caveolin-1's function in the context of a whole animal. Interestingly, we now report that the hearts of Cav-1 null mice are markedly abnormal, despite the fact that caveolin-1 is not expressed in cardiac myocytes. However, caveolin-1 is abundantly expressed in the nonmyocytic cells of the heart, i.e., cardiac fibroblasts and endothelia. Quantitative imaging studies of Cav-1 null hearts demonstrate a significantly enlarged right ventricular cavity and a thickened left ventricular wall with decreased systolic function. Histological analysis reveals myocyte hypertrophy with interstitial/perivascular fibrosis. Because caveolin-1 is thought to act as a negative regulator of the p42/44 MAP kinase cascade, we performed Western blot analysis with phospho-specific antibodies that only recognize activated ERK1/2. As predicted, the p42/44 MAP kinase cascade is hyperactivated in Cav-1 null heart tissue (i.e., interstitial fibrotic lesions) and isolated cardiac fibroblasts. In addition, endothelial and inducible nitric oxide synthase levels are dramatically upregulated. Thus loss of caveolin-1 expression drives p42/44 MAP kinase activation and cardiac hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00380.2002"xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Tang B."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Williams T.M."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Cohen A.W."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Lisanti M.P."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Russell R.G."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Weiss L.M."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Park D.S."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Kitsis R.N."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Tanowitz H.B."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Jelicks L.A."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Factor S.M."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Chandra M."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Pereira de Souza A."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Woodman S.E."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Shirani J."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/author | "Shtutin V."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/pages | "C457-74"xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/title | "Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/12388077 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12388077 |