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| http://purl.uniprot.org/citations/12388103 | http://www.w3.org/2000/01/rdf-schema#comment | "Connexin (Cx)43 gap junction channels are phosphorylated by numerous protein kinases, with the net effect typically being a reduction in gap junction communication (GJC). This reduction must result from a decrease in channel open probability, unitary conductance, or permselectivity, because previous results suggest that channel number is unaffected. Coexpression of v-Src with wild-type Cx43 (Cx43-wt) but not Cx43 with tyrosine to phenylalanine substitutions at 247 and 265 (Cx43-Y247,265F) resulted in reduced electrical and dye coupling but no change in single-channel amplitudes. EGF treatment of cells expressing Cx43-wt but not Cx43 with serine to alanine substitutions at 255, 279, and 282 (Cx43-S255,279,282A) resulted in reduced GJC, also with no change in single-channel amplitude. Dye coupling was reduced to a far greater extent than electrical coupling, suggesting that channel selectivity was also altered but with minimal effect on unitary conductance. The absence of Src- and MAPK-induced reductions in single-channel amplitude suggests that the decreases in GJC induced by these kinases result from reduced channel open probability and possibly altered selectivity."xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00214.2002"xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/author | "Lau A.F."xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/author | "Warn-Cramer B.J."xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/author | "Burt J.M."xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/author | "Cottrell G.T."xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/pages | "C511-20"xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/title | "Mechanism of v-Src- and mitogen-activated protein kinase-induced reduction of gap junction communication."xsd:string |
| http://purl.uniprot.org/citations/12388103 | http://purl.uniprot.org/core/volume | "284"xsd:string |
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