| http://purl.uniprot.org/citations/12388212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12388212 | http://www.w3.org/2000/01/rdf-schema#comment | "The actions of enteric 5-HT are terminated by 5-HT transporter (SERT)-mediated uptake, and gastrointestinal motility is abnormal in SERT -/-mice. We tested the hypothesis that adaptive changes in enteric 5-HT(3) receptors help SERT -/-mice survive despite inefficient 5-HT inactivation. Expression of mRNA encoding enteric 5-HT(3A) subunits was similar in SERT +/+ and -/-mice, but that of 5-HT(3B) subunits was fourfold less in SERT -/-mice. 5-HT(3B) mRNA was found, by in situ hybridization, in epithelial cells and enteric neurons. 5-HT evoked a fast inward current in myenteric neurons that was pharmacologically identified as 5-HT(3) mediated. The EC(50) of the 5-HT response was lower in SERT +/+ (18 microM) than in SERT -/-(36 microM) mice and desensitized rapidly in a greater proportion of SERT -/-neurons; however, peak amplitudes, steady-state current, and decay time constants were not different. Adaptive changes thus occur in the subunit composition of enteric 5-HT(3) receptors of SERT -/-mice that are reflected in 5-HT(3) receptor affinity and desensitization."xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00203.2002"xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/author | "Liu M.T."xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/author | "Gershon M.D."xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/author | "Murphy D.L."xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/author | "Rayport S."xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/pages | "G1398-411"xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/title | "Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter."xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/12388212 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12388212 |
| http://purl.uniprot.org/citations/12388212 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12388212 |
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