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http://purl.uniprot.org/citations/12390851http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12390851http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To study the association between immune response to hepatitis B vaccine and HLA-DRB1*02, 07, 09 genes in the population of Han nationality in Guangdong Province.

Methods

A total of 1 400 healthy college students of Han nationality from Guangdong Province were recruited in this study, who received standard courses of vaccination with recombinant hepatitis B virus vaccine at month 0, 1 and 6. Eight weeks after the final vaccination, the serum levels of anti-HBs antibody was examined with enzyme-linked immunosorbent assay (ELISA). Detection of HLA-DRB1*02, 07, 09 alleles were performed with PCR using sequence-specific primers in 118 individuals who failed to produce or produced insufficient antibodies (nonresponders or weak responders), 100 normal responders and 45 strong responders.

Results

The frequency of HLA-DRB1*07 in nonresponders or weak responders was significantly higher than that in normal or strong responders (15.25% vs 3.44%, P<0.05), while the frequency of HLA-DRB1*02 was much lower (5.08% vs 17.9%, P<0.05). The frequency of HLA-DRB1*09 showed no obvious difference between the 2 groups (19.49% vs 17.9%, P>0.05).

Conclusion

Failure or deficiency in the response to HBV vaccine is associated with the HLA-DRB1*07 gene, while HLA-DRB1*02 gene is related to the normal vaccination process or overreaction. Definite relation of HLA-DRB1*09 to the response to HBV vaccine is not found."xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/author"Qian Y."xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/author"Zhang L."xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/author"Hou J.L."xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/author"Liang X.M."xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/author"Luo K.X."xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/name"Di Yi Jun Yi Da Xue Xue Bao"xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/pages"67-69"xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/title"[Association of immune response to hepatitis B vaccine with HLA-DRB1*02, 07, 09 genes in the population of Han nationality in Guangdong Province]."xsd:string
http://purl.uniprot.org/citations/12390851http://purl.uniprot.org/core/volume"22"xsd:string
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