| http://purl.uniprot.org/citations/12391201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12391201 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously, we have shown that priming of therapeutic CD8(+) T cells in tumor vaccine-draining lymph nodes of mice vaccinated with GM-CSF secreting B16BL6 melanoma cells occurs independent of CD4 T cell help. In this study, we examined the contribution of the major costimulatory molecules, CD40 ligand (CD40L), CD80, and CD86, in the priming of CD8(+) T cells. Priming of therapeutic CD8(+) T cells by a GM-CSF-transduced tumor vaccine did not require CD40 and CD40L interactions, as therapeutic T cells could be generated from mice injected with anti-CD40L Ab and from CD40L knockout mice. However, costimulation via either CD80 or CD86 was required, as therapeutic T cells could be generated from mice injected with either anti-CD80 or anti-CD86 Ab alone, but administration of both Abs completely inhibited the priming of therapeutic T cells. Blocking experiments also identified that priming of therapeutic T cells in MHC class II-deficient mice required TNFR and IL-12 signaling, but signaling through CD40, lymphotoxin-betaR, or receptor activator of NF-kappaB was not essential. Thus, cross-priming of therapeutic CD8(+) T cells by a tumor vaccine transduced with GM-CSF requires TNFR, IL-12, and CD28 signaling."xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.9.4897"xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/author | "Fox B.A."xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/author | "Croft M."xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/author | "Hu H.M."xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/author | "Winter H."xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/author | "Urba W.J."xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/pages | "4897-4904"xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/title | "CD28, TNF receptor, and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/12391201 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12391201 |
| http://purl.uniprot.org/citations/12391201 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12391201 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-12391201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12391201 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-12391201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12391201 |
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| http://purl.uniprot.org/uniprot/#_P06342-mappedCitation-12391201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12391201 |
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| http://purl.uniprot.org/uniprot/#_P06345-mappedCitation-12391201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12391201 |
| http://purl.uniprot.org/uniprot/#_P06346-mappedCitation-12391201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12391201 |
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| http://purl.uniprot.org/uniprot/#_Q31184-mappedCitation-12391201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12391201 |