| http://purl.uniprot.org/citations/12391217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12391217 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous research has shown that many of the CD4 T cells from older mice do not form functional immune synapses after conjugation with peptide-pulsed APC. We now show that the defect lies at a very early stage in the cytoskeletal reorganization that precedes movement of protein kinases and their substrates to the TCR/APC interface. Antagonist peptides presented to T cells from young mice induce migration of talin (but not paxillin, vinculin, or F-actin) to the APC contact zone, but CD4 T cells from older donors typically fail to show the talin polarization response. A spreading assay in which contact with anti-CD3-coated slides induces CD4 T cells to assume a conical shape and develop lammelopodia also shows a decline with age in the proportion of T cells that can initiate cytoskeletal changes in response to this simplified stimulus. Finally, the transition from detergent-soluble to cytoskeletal forms of the p16, p21, and p23 isoforms of CD3zeta in response to CD3/CD4/CD28 cross-linking is much stronger in young than in old T cells. Thus, defects in cytoskeletal reorganization triggered by initial contact between TCR and peptide-bearing APC precede, and presumably contribute to, defective activation of protein kinase-mediated signals in the first few minutes of the activation cascade in T cells from aged mice."xsd:string |
| http://purl.uniprot.org/citations/12391217 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.9.5021"xsd:string |
| http://purl.uniprot.org/citations/12391217 | http://purl.uniprot.org/core/author | "Miller R.A."xsd:string |
| http://purl.uniprot.org/citations/12391217 | http://purl.uniprot.org/core/author | "Garcia G.G."xsd:string |
| http://purl.uniprot.org/citations/12391217 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12391217 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12391217 | http://purl.uniprot.org/core/pages | "5021-5027"xsd:string |
| http://purl.uniprot.org/citations/12391217 | http://purl.uniprot.org/core/title | "Age-dependent defects in TCR-triggered cytoskeletal rearrangement in CD4+ T cells."xsd:string |
| http://purl.uniprot.org/citations/12391217 | http://purl.uniprot.org/core/volume | "169"xsd:string |
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