| http://purl.uniprot.org/citations/12391611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12391611 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have implicated presenilin-1 (PS-1) in the processing of the amyloid precursor protein and Notch-1. We show that PS-1 has biological effects on differentiation and cell cycle control of neuronal precursor cells in vivo using PS-1-deficient mice. The expression of Class III beta-tubulin was upregulated throughout the neocortical primordia of PS-1-deficient E14 embryos, especially on the ventricular surface. The increased speed of migration of the immature neurons from the ventricular zone outward in the PS-1-deficient neocortical primordia was indicated by an in vivo bromodeoxyuridine (BrdU)-labeling assay and a DiI-labeling assay in slice culture. Furthermore, we investigated the cell cycle of neuronal precursor cells in the neocortical ventricular zone using an in vivo cumulative BrdU-labeling assay. The length of the cell cycle in the neocortical precursor cells of wild-type mice was 11.4 hr whereas that of the PS-1-deficient mice was 15.4 hr. Among all phases of the cell cycle, S-phase exhibited the most prominent change in length, increasing from 2.4 hr in the wild-type mice to 7.4 hr in the mutant mice. The distribution of beta-catenin was specifically affected in the ventricular zone of the PS-1-deficient mice. These findings suggest that PS-1 is involved in the differentiation and the cell cycle control of neuronal precursor cells in the ventricular proliferating zone of the neocortical primordium."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.org/dc/terms/identifier | "doi:10.1002/jnr.10430"xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Aizawa H."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Mori H."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Nakajima M."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Koseki H."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Kuroyanagi H."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Yuasa S."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Sakai T."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Koizumi K."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Shirasawa T."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Usami M."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/author | "Sahara N."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/name | "J Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/pages | "501-513"xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/title | "Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/12391611 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12391611 |
| http://purl.uniprot.org/citations/12391611 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12391611 |
| http://purl.uniprot.org/uniprot/P49769#attribution-D6E89B772AE0904B0AD3213978CEC935 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12391611 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-12391611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12391611 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-12391611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12391611 |