| http://purl.uniprot.org/citations/12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12393413 | http://www.w3.org/2000/01/rdf-schema#comment | "Iron accumulation in the liver in hereditary hemochromatosis (HH) has been shown to be highly variable. Some studies point to the importance of major histocompatibility complex (MHC) class I (MHC-I) and CD8(+) cells as modifiers of iron overload. In this report, using mice knockout for H2K(b-/-) and H2D(b-/-) genes, it is demonstrated that lack of classical MHC-I molecules results in a spontaneous increase of nonheme iron content in the liver (mainly located in the hepatocytes) when compared to wild-type mice. In CD8(-/-) and Rag2(-/-) mice, no spontaneous hepatic iron accumulation was observed. These results demonstrate for the first time that classical MHC-I molecules could be involved in the regulation of iron metabolism and contribute to the established genotype/phenotype discrepancies seen in HH."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-05-1565"xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/author | "de Sousa M."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/author | "Lemonnier F.A."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/author | "Rohrlich P."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/author | "Silva M.T."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/author | "Ribeiro E."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/author | "Cardoso E.M."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/author | "Macedo M.G."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/pages | "4239-4241"xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/title | "Increased hepatic iron in mice lacking classical MHC class I molecules."xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12393413 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12393413 |
| http://purl.uniprot.org/citations/12393413 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12393413 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393413 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393413 |
| http://purl.uniprot.org/uniprot/#_A0A482CGP7-mappedCitation-12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393413 |
| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393413 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G2-mappedCitation-12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393413 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G8-mappedCitation-12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393413 |
| http://purl.uniprot.org/uniprot/#_A0A494BA33-mappedCitation-12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393413 |
| http://purl.uniprot.org/uniprot/#_A0A494BAT0-mappedCitation-12393413 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393413 |