http://purl.uniprot.org/citations/12393708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12393708 | http://www.w3.org/2000/01/rdf-schema#comment | "The differentiation of eosinophils from hematopoietic precursors and their subsequent maturation, chemotaxis, and activation is primarily regulated by interleukin-5 (IL-5). To examine the effect of chronic IL-5 exposure on hematopoiesis, IL-5 transgenic (IL-5trg) mice and wild-type BALB/c (WT) mice were examined. In comparison to WT mice, a significant alteration in bone marrow hematopoiesis was observed in IL-5trg mice. Although the total number of myeloid progenitors in the bone marrow of IL-5trg mice was not significantly altered, the number of long-term culture-initiating cells (LTC-ICs) was 1.5-fold lower than that observed in WT mice. Furthermore, IL-5trg mice failed to demonstrate hematopoietic activity in long-term bone marrow cultures, which correlated with a significant decrease in the number of bone marrow mesenchymal/stromal progenitor (MSP) cells in these mice. In comparison to WT mice, a 10-fold decrease was observed in the number of fibroblast colony-forming units (CFU-Fs) in IL-5trg bone marrow. Hematopoietic activity of IL-5trg bone marrow cells was rescued by cultivation on preestablished layers of bone marrow-derived stromal cells. However, in contrast to bone marrow, increased hematopoietic activity was observed in the spleen and peripheral blood of IL-5trg mice. Likewise, the numbers of LTC-ICs and granulocyte-macrophage, macrophage, eosinophil, B-lymphocyte progenitors in the peripheral blood and spleen of IL-5trg mice were approximately 20-fold higher than in WT mice. A significant increase in CFU-F numbers was also observed in the spleens of IL-5trg mice compared with WT mice. Overall, our results suggest that constitutive overexpression of IL-5 can potentially induce colonization of spleen with MSP cells, which provides the necessary microenvironment for establishment of hematopoiesis in extramedullary sites."xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-03-0735"xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/author | "Rothenberg M.E."xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/author | "Sriramarao P."xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/author | "Broide D.H."xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/author | "Khaldoyanidi S."xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/author | "Sikora L."xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/pages | "863-868"xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/title | "Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen."xsd:string |
http://purl.uniprot.org/citations/12393708 | http://purl.uniprot.org/core/volume | "101"xsd:string |
http://purl.uniprot.org/citations/12393708 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12393708 |
http://purl.uniprot.org/citations/12393708 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12393708 |
http://purl.uniprot.org/uniprot/#_P05113-mappedCitation-12393708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12393708 |
http://purl.uniprot.org/uniprot/P05113 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12393708 |