| http://purl.uniprot.org/citations/12393911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12393911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12393911 | http://www.w3.org/2000/01/rdf-schema#comment | "Activity-dependent gene expression is thought to be important in shaping neuronal development and in modifying the protein content of neurons. Ca(2+) entry into neurons appears to be one of the key effectors of activity-dependent gene expression. Among the possible downstream targets of calcium, the protein phosphatase calcineurin represents a prime candidate. We hereby report that in cultured cerebellar granule cells the activation of the Ca(2+)/calcineurin pathway via either voltage- or ligand-operated Ca(2+) channels regulates MALS-1 and MALS-2 expression at the transcriptional level. These proteins are integral parts of the post-synaptic density and are also involved in receptor trafficking. MALS regulation is not at the level of mRNA stability and does not require de novo protein synthesis, thereby suggesting a direct pathway. These data suggest that Ca(2+) entry by means of calcineurin is capable of controlling the structure of the post-synaptic density by controlling the expression of key components at the transcriptional level."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m207826200"xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m207826200"xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/author | "Kramer D."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/author | "Kramer D."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/author | "Genazzani A.A."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/author | "Genazzani A.A."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/author | "Sanna B."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/author | "Sanna B."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/pages | "49585-49590"xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/pages | "49585-49590"xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/title | "The expression of the PDZ protein MALS-1/velis is regulated by calcium and calcineurin in cerebellar granule cells."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/title | "The expression of the PDZ protein MALS-1/velis is regulated by calcium and calcineurin in cerebellar granule cells."xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12393911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12393911 |
| http://purl.uniprot.org/citations/12393911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12393911 |
| http://purl.uniprot.org/citations/12393911 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12393911 |
| http://purl.uniprot.org/citations/12393911 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12393911 |