| http://purl.uniprot.org/citations/12397079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12397079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12397079 | http://www.w3.org/2000/01/rdf-schema#comment | "MRG15 is a novel chromodomain protein that is a member of a family of genes related to MORF4. MORF4 (mortality factor on chromosome 4) induces senescence in a subset of human tumor cell lines. Our previous results indicated that MRG15 (MORF-related gene on chromosome 15) could derepress the B-myb promoter by association with Rb. In this study, sucrose gradient analysis demonstrated that MRG15 was present in two distinct nuclear protein complexes, MAF1 (MRG15-associated factor 1) and MAF2. Rb was associated with MRG15 and PAM14 (a novel coil-coil protein) in MAF1, and a histone acetyl transferase, hMOF, was an MRG15 partner in MAF2. Analysis of deletion mutants of MRG15 indicated that the leucine zipper at the C-terminal region of MRG15 was important for the protein associations in MAF1 and that the N-terminal chromodomain was required for the assembly of the MAF2 protein complex. Consistent with these data was the fact that a histone acetyltransferase activity associated with MRG15 was lost when the chromodomain was deleted and that both mutant MRG15 proteins failed to activate the B-myb promoter. The various mechanisms by which MRG15 could activate gene transcription are discussed."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203839200"xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203839200"xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/author | "Lucchesi J.C."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/author | "Lucchesi J.C."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/author | "Pardo P.S."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/author | "Pardo P.S."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/author | "Pereira-Smith O.M."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/author | "Pereira-Smith O.M."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/author | "Leung J.K."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/author | "Leung J.K."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/pages | "50860-50866"xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/pages | "50860-50866"xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/title | "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/title | "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation."xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12397079 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12397079 |
| http://purl.uniprot.org/citations/12397079 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12397079 |