| http://purl.uniprot.org/citations/12397109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12397109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12397109 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulatory phosphorylation of the Cdc2p kinase by Wee1p-type kinases prevents eukaryotic cells from entering mitosis or meiosis at an inappropriate time. The canonical Wee1p kinase is a soluble protein that functions in the eukaryotic nucleus. All metazoa also have a membrane-associated Wee1p-like kinase named Myt1, and we describe the first genetic characterization of this less well-studied kinase. The Caenorhabditis elegans Myt1 ortholog is encoded by the wee-1.3 gene, and six dominant missense mutants prevent primary spermatocytes from entering M phase but do not affect either oocyte meiosis or any mitotic division. These six dominant wee-1.3(gf) mutations are located in a four amino acid region near the C terminus and they cause self-sterility of hermaphrodites. Second-site intragenic suppressor mutations in wee-1.3(gf) restore self-fertility to these dominant sterile hermaphrodites, permitting genetic dissection of this kinase. Ten intragenic wee-1.3 suppressor mutations were recovered and they form an allelic series that includes semi-dominant, hypomorphic and null mutations. These mutants reveal that WEE-1.3 protein is required for embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. This suggests that a novel, sperm-specific pathway negatively regulates WEE-1.3 to allow the G2/M transition of male meiosis I, and that dominant wee-1.3 mutants prevent this negative regulation."xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.129.21.5009"xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.129.21.5009"xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/author | "L'Hernault S.W."xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/author | "L'Hernault S.W."xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/author | "Lamitina S.T."xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/author | "Lamitina S.T."xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/pages | "5009-5018"xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/pages | "5009-5018"xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/title | "Dominant mutations in the Caenorhabditis elegans Myt1 ortholog wee-1.3 reveal a novel domain that controls M-phase entry during spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/title | "Dominant mutations in the Caenorhabditis elegans Myt1 ortholog wee-1.3 reveal a novel domain that controls M-phase entry during spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/12397109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12397109 |
| http://purl.uniprot.org/citations/12397109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12397109 |
| http://purl.uniprot.org/citations/12397109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12397109 |
| http://purl.uniprot.org/citations/12397109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12397109 |
| http://purl.uniprot.org/uniprot/O18209 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12397109 |
| http://purl.uniprot.org/uniprot/O18209#attribution-513C4DA7EBE2E311A72FA7A310AFA3A9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12397109 |