| http://purl.uniprot.org/citations/12403815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12403815 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulatory proteins have been identified in embryonic development of the endocrine pancreas. It is unknown whether these factors can also play a role in the formation of pancreatic endocrine cells from postnatal nonendocrine cells. The present study demonstrates that adult human pancreatic duct cells can be converted into insulin-expressing cells after ectopic, adenovirus-mediated expression of the class B basic helix-loop-helix factor neurogenin 3 (ngn3), which is a critical factor in embryogenesis of the mouse endocrine pancreas. Infection with adenovirus ngn3 (Adngn3) induced gene and/or protein expression of NeuroD/beta2, Pax4, Nkx2.2, Pax6, and Nkx6.1, all known to be essential for beta-cell differentiation in mouse embryos. Expression of ngn3 in adult human duct cells induced Notch ligands Dll1 and Dll4 and neuroendocrine- and beta-cell-specific markers: it increased the percentage of synaptophysin- and insulin-positive cells 15-fold in ngn3-infected versus control cells. Infection with NeuroD/beta2 (a downstream target of ngn3) induced similar effects. These data indicate that the Delta-Notch pathway, which controls embryonic development of the mouse endocrine pancreas, can also operate in adult human duct cells driving them to a neuroendocrine phenotype with the formation of insulin-expressing cells."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200203074"xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/author | "Heimberg H."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/author | "Pipeleers D."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/author | "Gradwohl G."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/author | "Madsen O."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/author | "Serup P."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/author | "Van De Casteele M."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/author | "Heremans Y."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/author | "in't Veld P."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/pages | "303-312"xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/title | "Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3."xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/12403815 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12403815 |
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