| http://purl.uniprot.org/citations/12406887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12406887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12406887 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DCs) are potent antigen-presenting cells that likely play multiple roles in human immunodeficiency virus type 1 (HIV-1) pathogenesis. We used the simian immunodeficiency virus (SIV)/macaque model to study the effects of infection on homeostatic chemokine expression and DC localization directly in secondary lymphoid tissues. SIV infection altered the expression of chemokines (CCL19/MIP-3beta, CCL21/ 6Ckine, and CCL20/MIP-3alpha) and of chemokine receptors (CCR7 and CCR6) that drive DC trafficking. CCL19/MIP-3beta, CCL20/MIP-3alpha, CCR6, and CCR7 expression increased in lymph nodes during the early systemic burst of viral replication (acute infection), whereas CCL21/6Ckine expression progressively decreased throughout disease to AIDS. Parallel with the SIV-induced perturbations in chemokine expression were changes in the expression of the DC-associated markers, DC-SIGN, DC-LAMP, and DECTIN-1. During AIDS, DC-LAMP mRNA expression levels were significantly reduced in lymph nodes and spleen, and DC-SIGN levels were significantly reduced in spleen. These findings suggest that the disruption of homeostatic chemokine expression is responsible, in part, for alterations in the networks of antigen-presenting cells in lymphoid tissues, ultimately contributing to systemic immunodeficiency."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-08-2653"xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-08-2653"xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/author | "Choi Y.K."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/author | "Choi Y.K."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/author | "Reinhart T.A."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/author | "Reinhart T.A."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/author | "Fallert B.A."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/author | "Fallert B.A."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/author | "Murphey-Corb M.A."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/author | "Murphey-Corb M.A."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/pages | "1684-1691"xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/pages | "1684-1691"xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/title | "Simian immunodeficiency virus dramatically alters expression of homeostatic chemokines and dendritic cell markers during infection in vivo."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/title | "Simian immunodeficiency virus dramatically alters expression of homeostatic chemokines and dendritic cell markers during infection in vivo."xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/12406887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12406887 |
| http://purl.uniprot.org/citations/12406887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12406887 |