| http://purl.uniprot.org/citations/12406903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12406903 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of cell death in activated naive T cells is not well understood. We examined the expression of A1, an antiapoptotic member of the Bcl-2 family, following activation of naive mouse splenocytes. A1 gene expression was strongly but transiently induced during the first day of activation, with a peak at 2 to 6 hours, whereas Bcl-2 mRNA was simultaneously transiently down-regulated. Transgenic (Tg) overexpression of A1-a in T cells via the lck distal promoter resulted in decreased apoptosis following activation either with concanavalin A or with antibodies to CD3 and CD28 and led to a doubling of T-cell yield by 5 days. Tg A1-a also partially protected thymocytes from several proapoptotic stimuli but did not protect T-cell blasts from cell death induced by reactivation via the T-cell receptor. Tg Bcl-2 and Tg A1-a showed a similar ability to reduce apoptosis in both resting and activated T cells. However, in activated splenocyte cultures, the increase in 5-day T-cell yield observed with Tg Bcl-2 was only half that produced by Tg A1-a. This difference could be attributed at least in part to the fact that A1, unlike Bcl-2, did not inhibit S-phase entry of activated cells. The A1 protein may represent an adaptation of the Bcl-2 gene family to the need for survival regulation in the context of a proliferative stimulus."xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-04-1229"xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://purl.uniprot.org/core/author | "Gonzalez J."xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://purl.uniprot.org/core/author | "Orlofsky A."xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://purl.uniprot.org/core/author | "Prystowsky M.B."xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12406903 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://purl.uniprot.org/core/pages | "2679-2685"xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://purl.uniprot.org/core/title | "A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells."xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/12406903 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12406903 |
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