| http://purl.uniprot.org/citations/12407025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12407025 | http://www.w3.org/2000/01/rdf-schema#comment | "Suppressor of cytokine signaling (SOCS)-1 is an inhibitory molecule for JAK, and its deficiency in mice leads to lymphocyte-dependent multi-organ disease and perinatal death. Crossing of SOCS-1(-/-) mice on an IFN-gamma(-/-), STAT1(-/-) and STAT6(-/-) background revealed that the fatal disease of SOCS-1(-/-) mice is also dependent on IFN-gamma/STAT1 and IL-4/STAT6 signaling pathways. Since IFN-gamma and IL-4 are representative T(h)1 and T(h)2 cytokines respectively, here we investigated the role of SOCS-1 in T(h) differentiation. Freshly isolated SOCS-1(-/-) CD4(+) T cells stimulated with anti-CD3 rapidly produced larger amounts of IFN-gamma and IL-4 than control cells, suggesting that these mutant T cells had already differentiated into T(h)1 and T(h)2 cells in vivo. In addition, SOCS-1(+/-) CD4(+) T cells cultured in vitro produced significantly larger amounts of IFN-gamma and IL-4 than SOCS-1(+/+) cells. Similarly, SOCS-1(+/-) CD4(+) T cells produced more IFN-gamma and IL-4 than SOCS-1(+/+) cells after infection with Listeria monocytogenes and Nippostrongyrus braziliensis respectively. Since IL-12-induced STAT4 and IL-4-induced STAT6 activation is sustained in SOCS-1(-/-) T cells, the enhanced T(h) functions in SOCS-1(-/-) and SOCS-1(+/-) mice appear to be due to the enhanced effects of these cytokines. These results suggest that SOCS-1 plays a regulatory role in both T(h)1 and T(h)2 polarizations."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxf094"xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Kishimoto T."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Fujimoto M."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Nakanishi K."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Tsutsui H."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Ueda H."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Naka T."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Kawase I."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Yumikura-Futatsugi S."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/author | "Xingshou O."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/pages | "1343-1350"xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/title | "A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo."xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/12407025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12407025 |
| http://purl.uniprot.org/citations/12407025 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12407025 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-12407025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12407025 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-12407025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12407025 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-12407025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12407025 |
| http://purl.uniprot.org/uniprot/#_P52633-mappedCitation-12407025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12407025 |
| http://purl.uniprot.org/uniprot/#_D3YU28-mappedCitation-12407025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12407025 |