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http://purl.uniprot.org/citations/12408764http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12408764http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the expression of extracellular signal-regulated kinase (ERK) and its relationship with clinicopathological characteristics of breast cancer as well as the effect of preoperative chemotherapy on ERK expression.

Methods

Expression of ERK-1 and ERK-2 protein was examined by Western blot in the breast cancer and normal breast (control) tissue of 48 patients, of whom 8 had received preoperative chemotherapy of 5'-deoxy-5-fluorouridine (5'-DFUR), with distribution of ERKs protein detected by immunohistochemical method.

Results

Expression of ERK-1 and ERK-2 protein was increased in tumor specimen as compared with control tissue (P < 0.01). A positive correlation was observed between ERK-1 and ERK-2 (r = 0.457, P < 0.01). Protein level of ERK-1 and ERK-2 was higher in stage III patients than in stage I and stage II patients (P < 0.05). Expression of both ERK-1 and ERK-2 in the carcinoma tissue was decreased in patients who had received preoperative chemotherapy of 5'-DFUR. ERK-1 and ERK-2 proteins were mainly located in the cytoplasm.

Conclusion

The hyperexpression of ERK may play an important role in the initiation and development of human breast cancer. Preoperative chemotherapy of 5'-DFUR is able to partially inhibit ERK expression."xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/author"Wang S."xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/author"Wang Z."xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/author"Yu Y."xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/author"Zhu F."xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/author"Ye Y."xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/author"Qiao X."xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/name"Zhonghua Zhong Liu Za Zhi"xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/pages"360-363"xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/title"Expression of extracellular signal-regulated kinase and its relationship with clinicopathological characteristics of breast cancer."xsd:string
http://purl.uniprot.org/citations/12408764http://purl.uniprot.org/core/volume"24"xsd:string
http://purl.uniprot.org/citations/12408764http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12408764
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