| http://purl.uniprot.org/citations/12408804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12408804 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12408804 | http://www.w3.org/2000/01/rdf-schema#comment | "Asymmetric body axis formation is central to metazoan development. Dictyostelium establishes an anterior/posterior axis utilizing seven-transmembrane cAMP morphogen receptors (CARs) and GSK3-mediated signal transductions that has a parallel with metazoan Wnt/Frizzled-GSK3 pathways. In Dictyostelium, GSK3 promotes posterior cell patterning but inhibits anterior cell differentiation. Tyrosine kinase ZAK1 mediates GSK3 activation. We now show that CAR4 regulates a tyrosine phosphatase that inhibits GSK3 activity. We have also identified essential phosphotyrosines in GSK3, confirmed their role in activated/deactivated regulation and cell fate decisions, and relate them to the predicted 3D structure of GSK3beta. CARs differentially regulate GSK3 activity by selectively activating a tyrosine phosphatase or kinase for pattern formation. The findings may provide a comparative understanding of CAR-GSK3 and Wnt/Frizzled-GSK3 pathways."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00269-1"xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00269-1"xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/author | "Harwood A.J."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/author | "Harwood A.J."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/author | "Kimmel A.R."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/author | "Kimmel A.R."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/author | "Kim L."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/author | "Kim L."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/pages | "523-532"xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/pages | "523-532"xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/title | "Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/title | "Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice."xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/12408804 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12408804 |
| http://purl.uniprot.org/citations/12408804 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12408804 |
| http://purl.uniprot.org/citations/12408804 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12408804 |
| http://purl.uniprot.org/citations/12408804 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12408804 |