| http://purl.uniprot.org/citations/12408844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12408844 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12408844 | http://www.w3.org/2000/01/rdf-schema#comment | "In a genetic screen for genes that control synapse development, we have identified spinster (spin), which encodes a multipass transmembrane protein. spin mutant synapses reveal a 200% increase in bouton number and a deficit in presynaptic release. We demonstrate that spin is expressed in both nerve and muscle and is required both pre- and postsynaptically for normal synaptic growth. We have localized Spin to a late endosomal compartment and present evidence for altered endosomal/lysosomal function in spin. We also present evidence that synaptic overgrowth in spin is caused by enhanced/misregulated TGF-beta signaling. TGF-beta receptor mutants show dose-dependent suppression of synaptic overgrowth in spin. Furthermore, mutations in Dad, an inhibitory Smad, cause synapse overgrowth. We present a model for synaptic growth control with implications for the etiology of lysosomal storage and neurodegenerative disease."xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)01014-0"xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)01014-0"xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/author | "Sweeney S.T."xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/author | "Sweeney S.T."xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/author | "Davis G.W."xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/author | "Davis G.W."xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/pages | "403-416"xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/pages | "403-416"xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/title | "Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation."xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/title | "Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation."xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/12408844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12408844 |
| http://purl.uniprot.org/citations/12408844 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12408844 |
| http://purl.uniprot.org/citations/12408844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12408844 |
| http://purl.uniprot.org/citations/12408844 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12408844 |
| http://purl.uniprot.org/uniprot/Q9H2V7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12408844 |
| http://purl.uniprot.org/uniprot/Q9GQQ0 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12408844 |