| http://purl.uniprot.org/citations/12413694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12413694 | http://www.w3.org/2000/01/rdf-schema#comment | "Programmed cell death (apoptosis) is crucial for thymocyte development. We analyzed the role of the ubiquitin (Ub)-proteasome pathway in dexamethasone-triggered and TCR-mediated apoptosis in fetal thymic organ culture (FTOC). Proteasome activity was increased in apoptotic thymocytes, as visualized by active-site labeling of proteasomal beta subunits. The activity of deubiquitinating enzymes in murine apoptotic thymocytes was likewise examined by active-site labeling. We show that the deubiquitinating enzyme USP7 (HAUSP) is proteolytically processed upon dexamethasone-, gamma-irradiation-, and antigen-induced cell death. Such processing of HAUSP does not occur in caspase 3-/-thymocytes, or upon pretreatment of wild type thymocytes with the general caspase inhibitor ZVAD-fmk. Thus, our results suggest that thymocyte apoptosis leads to modification of deubiquitinating enzymes by caspase activity and may provide an additional link between the ubiquitin-proteasome pathway and the caspase cascade during programmed cell death."xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0161-5890(02)00123-2"xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/author | "Ploegh H.L."xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/author | "Maehr R."xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/author | "Borodovsky A."xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/author | "Furman M.H."xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/author | "Maurice M.M."xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/author | "Vugmeyster Y."xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/pages | "431-441"xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/title | "The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP)."xsd:string |
| http://purl.uniprot.org/citations/12413694 | http://purl.uniprot.org/core/volume | "39"xsd:string |
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