| http://purl.uniprot.org/citations/12414514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12414514 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent evidence supports the notion that tissue OX2 (CD200) constitutively provides down-regulatory signals to myeloid-lineage cells via CD200-receptor (CD200R). Thus, mice lacking CD200 (CD200(-/-)) show increased susceptibility to and accelerated onset of tissue-specific autoimmunity. In the retina there is extensive expression of CD200 on neurons and retinal vascular endothelium. We show here that retinal microglia in CD200(-/-) mice display normal morphology, but unlike microglia from wild-type CD200(+/+) mice are present in increased numbers and most significantly, express inducible nitric oxide synthase (NOS2), a macrophage activation marker. Onset and severity of uveitogenic peptide (1-20) of interphotoreceptor retinoid-binding protein-induced experimental autoimmune uveoretinitis is accelerated in CD200(-/-) mice and although tissue destruction appears no greater than seen in CD200(+/+) mice, there is continued increased ganglion and photoreceptor cell apoptosis. Myeloid cell infiltrate was increased in CD200(-/-) mice during experimental autoimmune uveoretinitis, although NOS2 expression was not heightened. The results indicate that the CD200:CD200R axis regulates retinal microglial activation. In CD200(-/-) mice the release of suppression of tonic macrophage activation, supported by increased NOS2 expression in the CD200(-/-) steady state accelerates disease onset but without any demonstration of increased target organ/tissue destruction."xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)64444-6"xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/author | "Hoek R.M."xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/author | "Forrester J.V."xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/author | "Sedgwick J.D."xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/author | "Liversidge J."xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/author | "Dick A.D."xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/author | "Broderick C."xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/pages | "1669-1677"xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/title | "Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis."xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/12414514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12414514 |
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