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| http://purl.uniprot.org/citations/12414794 | http://www.w3.org/2000/01/rdf-schema#comment | "Epidermal growth factor induction of c-jun expression requires ATF1 and MEF2 sites in the c-jun promoter. We find that activation of the c-jun promoter through the ATF1 site requires phosphorylation of ATF1 at serine 63. A serine 63 to alanine mutation of ATF1 acts to block epidermal growth factor (EGF) induction of a transfected c-jun gene. ATF1 can be phosphorylated by mitogen- and stress-activated protein kinase 1 (MSK1), which is activated by EGF and ERK1/2. Kinase-dead MSK1 mutants blocked EGF induction of a transfected c-jun gene suggesting that MSK1 or a similar family member is required for induced c-jun expression. Use of the MEK1 inhibitor U0126 and dominant negative MEK1 further showed that MSK1 activation and c-jun induction require the ERK pathway. In contrast, a JNK inhibitor blocked EGF induction of c-jun expression but not ATF1 phosphorylation. These results show that the two MAPK pathways, ERK and JNK, are required for EGF-induced c-jun expression and that the ERK pathway acts through downstream phosphorylation of ATF1."xsd:string |
| http://purl.uniprot.org/citations/12414794 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m209799200"xsd:string |
| http://purl.uniprot.org/citations/12414794 | http://purl.uniprot.org/core/author | "Gupta P."xsd:string |
| http://purl.uniprot.org/citations/12414794 | http://purl.uniprot.org/core/author | "Prywes R."xsd:string |
| http://purl.uniprot.org/citations/12414794 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12414794 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12414794 | http://purl.uniprot.org/core/pages | "50550-50556"xsd:string |
| http://purl.uniprot.org/citations/12414794 | http://purl.uniprot.org/core/title | "ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression."xsd:string |
| http://purl.uniprot.org/citations/12414794 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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