| http://purl.uniprot.org/citations/12415263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12415263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12415263 | http://www.w3.org/2000/01/rdf-schema#comment | "The evolutionary origin of adaptive immune receptors is not understood below the phylogenetic level of the jawed vertebrates. We describe here a strategy for the selective cloning of cDNAs encoding secreted or transmembrane proteins that uses a bacterial plasmid (Amptrap) with a defective beta-lactamase gene. This method requires knowledge of only a single target motif that corresponds to as few as three amino acids; it was validated with major histocompatibility complex genes from a cartilaginous fish. Using this approach, we identified families of genes encoding secreted proteins with two diversified immunoglobulin-like variable (V) domains and a chitin-binding domain in amphioxus, a protochordate. Thus, multigenic families encoding diversified V regions exist in a species lacking an adaptive immune response."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni849"xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni849"xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/author | "Cannon J.P."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/author | "Cannon J.P."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/author | "Haire R.N."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/author | "Haire R.N."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/author | "Litman G.W."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/author | "Litman G.W."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/pages | "1200-1207"xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/pages | "1200-1207"xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/title | "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/title | "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate."xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/12415263 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12415263 |
| http://purl.uniprot.org/citations/12415263 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12415263 |
| http://purl.uniprot.org/citations/12415263 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12415263 |
| http://purl.uniprot.org/citations/12415263 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12415263 |