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http://purl.uniprot.org/citations/12419225http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12419225http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12419225http://www.w3.org/2000/01/rdf-schema#comment"Adenosine deaminases that act on RNA (ADARs) are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA). Here we demonstrate that ADARs are not required for RNA interference (RNAi) and that they do not antagonize the pathway to a detectable level when RNAi is initiated by injecting dsRNA. We find, however, that transgenes expressed in the somatic tissues of wild-type animals are silenced in strains with deletions in the two genes encoding ADARs, adr-1 and adr-2. Transgene-induced gene silencing in adr-1;adr-2 mutants depends on genes required for RNAi, suggesting that a dsRNA intermediate is involved. In wild-type animals we detect edited dsRNA corresponding to transgenes, and we propose that editing of this dsRNA prevents somatic transgenes from initiating RNAi in wild-type animals."xsd:string
http://purl.uniprot.org/citations/12419225http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(02)00649-4"xsd:string
http://purl.uniprot.org/citations/12419225http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(02)00649-4"xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/author"Bass B.L."xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/author"Bass B.L."xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/author"Knight S.W."xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/author"Knight S.W."xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/name"Mol. Cell"xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/name"Mol. Cell"xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/pages"809-817"xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/pages"809-817"xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/title"The role of RNA editing by ADARs in RNAi."xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/title"The role of RNA editing by ADARs in RNAi."xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/12419225http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/12419225http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12419225
http://purl.uniprot.org/citations/12419225http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12419225
http://purl.uniprot.org/citations/12419225http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12419225
http://purl.uniprot.org/citations/12419225http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12419225
http://purl.uniprot.org/uniprot/Q9U3D6http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/12419225
http://purl.uniprot.org/uniprot/Q22618http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/12419225