| http://purl.uniprot.org/citations/12421483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12421483 | http://www.w3.org/2000/01/rdf-schema#comment | "AimTo determine the effect of CYP2D6*10 genotype on propafenone pharmacodynamics in Chinese patients with ventricular arrhythmia.MethodsSeventeen Chinese patients with ventricular premature contractions (VPC> or =1000/d) were recruited. They were normal in routine laboratory testing and administered propafenone hydrochloride 450-600 mg per day in three divided doses. Twelve lead cardiogram and 24 h Holter monitoring were performed before and after 7 d treatment of propafenone. Steady-state peak and trough concentrations of propafenone were measured by HPLC method. CYP2D6*10 genotypes of patients were assayed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).ResultsTotal inhibitory rate of VPC was 79.9 % in 17 patients with ventricular arrhythmia after propafenone treatment. PR interval prolongation was increased from 0.146 s+/-0.018 s to 0.161 s+/-0.022 s (P<0.05). CYP2D6 genotypes played an important role in plasma levels and effects of propafenone. In 450 mg/d group, patients with homozygous mutant of CYP2D6*10 not only had a Cmax of propafenone two times as high as those of wild-type genotype, but also showed a two fold higher inhibitory rate of VPC compared with those with homozygous CYP2D6*1 (P<0.05).ConclusionCYP2D6*10 genotype is relevant to decreased activity of CYP2D6 enzyme in Chinese patients. Elevated plasma concentration is consistent with better efficacy of propafenone in patients with ventricular arrhythmia."xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/author | "Zhang Y.D."xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/author | "Zhang F.M."xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/author | "Huang Y.Z."xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/author | "Cai W.M."xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/name | "Acta Pharmacol Sin"xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/pages | "1040-1044"xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/title | "Effect of CYP2D6*10 genotype on propafenone pharmacodynamics in Chinese patients with ventricular arrhythmia."xsd:string |
| http://purl.uniprot.org/citations/12421483 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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