| http://purl.uniprot.org/citations/12421911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12421911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12421911 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphocyte activation gene (LAG)-3 (CD223) is a CD4-related activation-induced cell surface molecule that binds to MHC class II molecules with high affinity and negatively regulates T cell expansion and homeostasis. In this study, we show that LAG-3 inhibits CD4-dependent, but not CD4-independent, T cell function via its cytoplasmic domain. Although high affinity interaction with MHC class II molecules is essential for LAG-3 function, tailless LAG-3 does not compete with CD4 for ligand binding. A single lysine residue (K468) within a conserved "KIEELE" motif is essential for interaction with downstream signaling molecules. These data provide insight into the mechanism of action of this important T cell regulatory molecule."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.10.5392"xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.169.10.5392"xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/author | "Vignali D.A."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/author | "Vignali D.A."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/author | "Workman C.J."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/author | "Workman C.J."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/author | "Dugger K.J."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/author | "Dugger K.J."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/pages | "5392-5395"xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/pages | "5392-5395"xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/title | "Molecular analysis of the negative regulatory function of lymphocyte activation gene-3."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/title | "Molecular analysis of the negative regulatory function of lymphocyte activation gene-3."xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://purl.uniprot.org/core/volume | "169"xsd:string |
| http://purl.uniprot.org/citations/12421911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12421911 |
| http://purl.uniprot.org/citations/12421911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12421911 |
| http://purl.uniprot.org/citations/12421911 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12421911 |
| http://purl.uniprot.org/citations/12421911 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12421911 |