| http://purl.uniprot.org/citations/12424381 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12424381 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear localization of the transcriptional activator NF-kappaB (nuclear factor kappaB) is controlled in mammalian cells by three isoforms of NF-kappaB inhibitor protein: IkappaBalpha, -beta, and - epsilon. Based on simplifying reductions of the IkappaB-NF-kappaB signaling module in knockout cell lines, we present a computational model that describes the temporal control of NF-kappaB activation by the coordinated degradation and synthesis of IkappaB proteins. The model demonstrates that IkappaBalpha is responsible for strong negative feedback that allows for a fast turn-off of the NF-kappaB response, whereas IkappaBbeta and - epsilon function to reduce the system's oscillatory potential and stabilize NF-kappaB responses during longer stimulations. Bimodal signal-processing characteristics with respect to stimulus duration are revealed by the model and are shown to generate specificity in gene expression."xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1071914"xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/author | "Baltimore D."xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/author | "Scott M.L."xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/author | "Hoffmann A."xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/author | "Levchenko A."xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/pages | "1241-1245"xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/title | "The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation."xsd:string |
| http://purl.uniprot.org/citations/12424381 | http://purl.uniprot.org/core/volume | "298"xsd:string |
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