| http://purl.uniprot.org/citations/12426399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12426399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12426399 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA-PKcs is the catalytic subunit of the DNA-dependent protein kinase (DNA-PK) complex that functions in the non-homologous end-joining of double-strand breaks, and it has been shown previously to have a role in telomere capping. In particular, DNA-PKcs deficiency leads to chromosome fusions involving telomeres produced by leading-strand synthesis. Here, by generating mice doubly deficient in DNA-PKcs and telomerase (Terc(-/-)/DNA-PKcs(-/-)), we demonstrate that DNA-PKcs also has a fundamental role in telomere length maintenance. In particular, Terc(-/-)/DNA-PKcs(-/-) mice displayed an accelerated rate of telomere shortening when compared with Terc(-/-) controls, suggesting a functional interaction between both activities in maintaining telomere length. In addition, we also provide direct demonstration that DNA-PKcs is essential for both end-to-end fusions and apoptosis triggered by critically short telomeres. Our data predict that, in telomerase-deficient cells, i.e. human somatic cells, DNA-PKcs abrogation may lead to a faster rate of telomere degradation and cell cycle arrest in the absence of increased apoptosis and/or fusion of telomere-exhausted chromosomes. These results suggest a critical role of DNA-PKcs in both cancer and aging."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf593"xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf593"xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Blasco M.A."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Blasco M.A."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Bailey S.M."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Bailey S.M."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Taccioli G.E."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Taccioli G.E."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Franco S."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Franco S."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Espejel S."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Espejel S."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Gae D."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Gae D."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Sgura A."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/author | "Sgura A."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/pages | "6275-6287"xsd:string |
| http://purl.uniprot.org/citations/12426399 | http://purl.uniprot.org/core/pages | "6275-6287"xsd:string |