| http://purl.uniprot.org/citations/12427738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12427738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12427738 | http://www.w3.org/2000/01/rdf-schema#comment | "The integrity of the carboxyl-terminal BRCT repeat region is critical for BRCA1 tumor suppressor function; however, the molecular details of how a number of clinically derived BRCT missense mutations affect BRCA1 function remain largely unknown. Here we assess the structural response of the BRCT tandem repeat domain to a well characterized, cancer-associated single amino acid substitution, Met-1775 --> Arg-1775. The structure of BRCT-M1775R reveals that the mutated side chain is extruded from the protein hydrophobic core, thereby altering the protein surface. Charge-charge repulsion, rearrangement of the hydrophobic core, and disruption of the native hydrogen bonding network at the interface between the two BRCT repeats contribute to the conformational instability of BRCT-M1775R. Destabilization and global unfolding of the mutated BRCT domain at physiological temperatures explain the pleiotropic molecular and genetic defects associated with the BRCA1-M1775R protein."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210019200"xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210019200"xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/author | "Williams R.S."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/author | "Williams R.S."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/author | "Glover J.N."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/author | "Glover J.N."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/pages | "2630-2635"xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/pages | "2630-2635"xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/title | "Structural consequences of a cancer-causing BRCA1-BRCT missense mutation."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/title | "Structural consequences of a cancer-causing BRCA1-BRCT missense mutation."xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12427738 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12427738 |
| http://purl.uniprot.org/citations/12427738 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12427738 |
| http://purl.uniprot.org/citations/12427738 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12427738 |
| http://purl.uniprot.org/citations/12427738 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12427738 |
| http://purl.uniprot.org/uniprot/P38398 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12427738 |
| http://purl.uniprot.org/uniprot/P38398#attribution-B0ED475EB8CF2C7ABAD6735063872330 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12427738 |