| http://purl.uniprot.org/citations/12432063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12432063 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Catenin is a multi-functional cellular component and a substrate for several protein kinases. Here we investigated the interaction of protein kinase CKII (casein kinase II) and beta-catenin. We show that CKII phosphorylates the N-terminal region of beta-catenin and we identified Ser29, Thr102, and Thr112 as substrates for the enzyme. We provide evidence that CKII regulates the cytoplasmic stability of beta-catenin and acts synergistically with GSK-3beta in the multi-protein complex that controls the degradation of beta-catenin. In comparing wild-type and Ser/Thr-mutant beta-catenin, a decreased affinity of the mutant protein to alpha-catenin was observed. Moreover, kinase assays in vitro demonstrate a CKII-dependent increase in the binding of wild-type beta-catenin with alpha-catenin. In line with that, cells expressing Ser/Thr-mutant beta-catenin exhibit an increased migratory potential, which correlates with an enhanced cytosolic localization and a reduced association with the cytoskeleton of the mutant protein. From these results we conclude that CKII regulates the function of beta-catenin in the cadherin adhesion complex as well as its cytoplasmic stability."xsd:string |
| http://purl.uniprot.org/citations/12432063 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.00154"xsd:string |
| http://purl.uniprot.org/citations/12432063 | http://purl.uniprot.org/core/author | "Kemler R."xsd:string |
| http://purl.uniprot.org/citations/12432063 | http://purl.uniprot.org/core/author | "Bek S."xsd:string |
| http://purl.uniprot.org/citations/12432063 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12432063 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/12432063 | http://purl.uniprot.org/core/pages | "4743-4753"xsd:string |
| http://purl.uniprot.org/citations/12432063 | http://purl.uniprot.org/core/title | "Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability."xsd:string |
| http://purl.uniprot.org/citations/12432063 | http://purl.uniprot.org/core/volume | "115"xsd:string |
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