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| http://purl.uniprot.org/citations/12433361 | http://www.w3.org/2000/01/rdf-schema#comment | "We report intriguing aspects of the contribution of IL-15Ralpha to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15Ralpha, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15/IL-15Ralpha complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constant reappearance of IL-15 on plasma membranes. This complex contributes to the long survival of T cells expressing IL-15Ralpha after IL-15 withdrawal. Finally, these complexes on activated monocytes present IL-15 in trans to target cells such as CD8(+) T cells that express only IL-2/15Rbeta and gammac upon cell-cell interaction."xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00429-6"xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/author | "Dubois S."xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/author | "Waldmann T.A."xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/author | "Tagaya Y."xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/author | "Mariner J."xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/pages | "537-547"xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/title | "IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells."xsd:string |
| http://purl.uniprot.org/citations/12433361 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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