| http://purl.uniprot.org/citations/12433679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12433679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12433679 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have revealed that that approximately 10% to 15% of multiple myelomas (MMs) are characterized by a reciprocal t(4;14)(p16;q32) translocation that activates expression of FGFR3 and creates an IGH/MMSET fusion transcript. Current data suggest that activation of FGFR3 is the oncogenic consequence of this rearrangement. Using a combination of microarray profiling, reverse transcriptase-polymerase chain reaction (RT-PCR), and interphase fluorescence in situ hybridization (FISH), we show that 32 (18%) of 178 newly diagnosed cases of MM harbor the t(4;14)(p16;q32). Importantly, 32% of these cases lack expression of FGFR3, yet express MMSET and have an IGH/MMSET fusion transcript. Interphase FISH showed that whereas the IGH/MMSET fusion was present in more than 80% of the clonotypic plasma cells in these novel cases, there was typically a complete loss of one copy of FGFR3. These data indicate that the t(4;14)(p16;q32) and loss of FGFR3 occurred at a very early stage and suggest that activation of MMSET, not FGFR3, may be the critical transforming event of this recurrent translocation."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-09-2801"xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-09-2801"xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Tian E."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Tian E."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Zhan F."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Zhan F."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Barlogie B."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Barlogie B."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Santra M."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Santra M."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Shaughnessy J. Jr."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/author | "Shaughnessy J. Jr."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/pages | "2374-2376"xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/pages | "2374-2376"xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/title | "A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/title | "A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript."xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/12433679 | http://purl.uniprot.org/core/volume | "101"xsd:string |