| http://purl.uniprot.org/citations/12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12433685 | http://www.w3.org/2000/01/rdf-schema#comment | "Posttranslational processing of Ras proteins has attracted considerable interest as a potential target for anticancer drug discovery. Rce1 encodes an endoprotease that facilitates membrane targeting of Ras and other prenylated proteins by releasing the carboxyl-terminal 3 amino acids (ie, the -AAX of the CAAX motif). Homozygous Rce1 mutant embryos (Rce1(-/-)) die late in gestation. To characterize the role of Rce1 in hematopoiesis, we performed adoptive transfers and investigated cells from the recipients. Rce1(-/-) fetal liver cells rescued lethally irradiated recipients and manifested normal long-term repopulating potential in competitive repopulation assays. The recipients of Rce1(-/-) cells developed modest elevations in mature myeloid cells (neutrophils + monocytes), but remained well. Bone marrow cells from mice that received transplants of Rce1(-/-) activated extracellular signal-related kinase (ERK) normally in response to granulocyte-macrophage colony-stimulating factor. These data suggest that pharmacologic inhibitors of Rce1 will have minimal effects on normal hematopoietic cells."xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2002-07-2250"xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/author | "Young S.G."xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/author | "Taylor B.R."xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/author | "Shannon K.M."xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/author | "Aiyagari A.L."xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/author | "Aurora V."xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/pages | "2250-2252"xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/title | "Hematologic effects of inactivating the Ras processing enzyme Rce1."xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/12433685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12433685 |
| http://purl.uniprot.org/citations/12433685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12433685 |
| http://purl.uniprot.org/uniprot/#_A0A286YDK5-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U4-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_A0A286YCK9-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_A0A286YCQ7-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_A0A494BAL8-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_P57791-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_P01111-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_P01112-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_P01116-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |
| http://purl.uniprot.org/uniprot/#_Q99KQ3-mappedCitation-12433685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433685 |