| http://purl.uniprot.org/citations/12433842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12433842 | http://www.w3.org/2000/01/rdf-schema#comment | "In neonatal cardiomyocytes, activation of the G(q)-coupled alpha(1)-adrenergic receptor (alpha(1)AR) induces hypertrophy by activating mitogen-activated protein kinases, including c-Jun NH(2)-terminal kinase (JNK). Here, we show that JNK activation is essential for alpha(1)AR-induced hypertrophy, in that alpha(1)AR-induced hypertrophic responses, such as reorganization of the actin cytoskeleton and increased protein synthesis, could be blocked by expressing the JNK-binding domain of JNK-interacting protein-1, a specific inhibitor of JNK. We also identified the classes and subunits of G proteins that mediate alpha(1)AR-induced JNK activation and hypertrophic responses by generating several recombinant adenoviruses that express polypeptides capable of inhibiting the function of specific G-protein subunits. alpha(1)AR-induced JNK activation was inhibited by the expression of carboxyl terminal regions of Galpha(q), Galpha(12), and Galpha(13). JNK activation was also inhibited by the Galpha(q/11)- or Galpha(12/13)-specific regulator of G-protein signaling (RGS) domains and by C3 toxin but was not affected by treatment with pertussis toxin or by expression of the carboxyl terminal region of G protein-coupled receptor kinase 2, a polypeptide that sequesters Gbetagamma. alpha(1)AR-induced hypertrophic responses were inhibited by Galpha(q/11)- and Galpha(12/13)-specific RGS domains, C3 toxin, and the carboxyl terminal region of G protein-coupled receptor kinase 2 but not by pertussis toxin. Activation of Rho was inhibited by carboxyl terminal regions of Galpha(12) and Galpha(13) but not by Galpha(q). Our findings suggest that alpha(1)AR-induced hypertrophic responses are mediated in part by a Galpha(12/13)-Rho-JNK pathway, in part by a G(q/11)-JNK pathway that is Rho independent, and in part by a Gbetagamma pathway that is JNK independent."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000043282.39776.7c"xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Nishida M."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Maruyama Y."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Wada T."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Tanabe S."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Sugimoto Y."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Kozasa T."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Nagao T."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Kurose H."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/author | "Turner J.H."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/pages | "961-969"xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/title | "Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/12433842 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12433842 |
| http://purl.uniprot.org/citations/12433842 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12433842 |
| http://purl.uniprot.org/uniprot/#_O14775-mappedCitation-12433842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433842 |
| http://purl.uniprot.org/uniprot/#_P21731-mappedCitation-12433842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433842 |
| http://purl.uniprot.org/uniprot/#_P25100-mappedCitation-12433842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433842 |
| http://purl.uniprot.org/uniprot/#_P16520-mappedCitation-12433842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433842 |
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| http://purl.uniprot.org/uniprot/#_P35368-mappedCitation-12433842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12433842 |