| http://purl.uniprot.org/citations/12435397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12435397 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12435397 | http://www.w3.org/2000/01/rdf-schema#comment | "TEL is a nuclear phosphoprotein that belongs to a member of the ETS family transcription factors. TEL acts as a tumor suppressor and is essential for establishing hematopoiesis in neonatal bone marrow. Because TEL possesses multiple putative mitogen-activated protein (MAP) kinase phosphorylation sites, we here investigated functional regulation of TEL via stress signaling pathways. We showed that TEL becomes phosphorylated in vivo by activated p38 but not by JNK1. The constitutive and inducible phosphorylation sites were found to be Ser(22) and Ser(257), respectively. TEL bound to p38 and was directly phosphorylated in vitro by p38. In vivo p38-dependent phosphorylation reduced trans-repressional abilities of TEL through ETS-binding consensus site. These data indicate that TEL's functions are potentially regulated by p38 which is activated by various kinds of stresses. TEL could be a constituent downstream of the specific MAP kinase in the signal transduction system."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02588-3"xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)02588-3"xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Arai H."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Arai H."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Hirai H."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Hirai H."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Mitani K."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Mitani K."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Maki K."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Maki K."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Kurokawa M."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Kurokawa M."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Waga K."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/author | "Waga K."xsd:string |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12435397 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |