| http://purl.uniprot.org/citations/12435733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12435733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12435733 | http://www.w3.org/2000/01/rdf-schema#comment | "Perlecan, a ubiquitous basement membrane heparan sulfate proteoglycan, plays key roles in blood vessel growth and structural integrity. We discovered that the C terminus of perlecan potently inhibited four aspects of angiogenesis: endothelial cell migration, collagen-induced endothelial tube morphogenesis, and blood vessel growth in the chorioallantoic membrane and in Matrigel plug assays. The C terminus of perlecan was active at nanomolar concentrations and blocked endothelial cell adhesion to fibronectin and type I collagen, without directly binding to either protein; henceforth we have named it "endorepellin." We also found that endothelial cells possess a significant number of high affinity (K(d) of 11 nm) binding sites for endorepellin and that endorepellin binds endostatin and counteracts its anti-angiogenic effects. Thus, endorepellin represents a novel anti-angiogenic product, which may retard tumor neovascularization and hence tumor growth in vivo."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210445200"xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m210445200"xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "Sweeney S.M."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "Sweeney S.M."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "Iozzo R.V."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "Iozzo R.V."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "San Antonio J.D."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "San Antonio J.D."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "Mongiat M."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/author | "Mongiat M."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/pages | "4238-4249"xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/pages | "4238-4249"xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/title | "Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/title | "Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan."xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12435733 | http://purl.uniprot.org/core/volume | "278"xsd:string |