| http://purl.uniprot.org/citations/12435739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12435739 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic studies have demonstrated that the basic helix-loop-helix protein E2A is an essential transcription factor in B lymphocyte lineage commitment and differentiation. However, the mechanism underlying E2A-mediated transcription regulation is not fully understood. Here, we investigated the physical and genetic interactions between E2A and co-activators histone acetyltransferases (HATs) in B cells. Gel filtration analysis of human pre-B cell nuclear extract showed that E2A co-elutes with the HATs p300, CBP, and PCAF. A co-immunoprecipitation assay further demonstrated that a fraction of endogenous E2A proteins is associated with each of the three HATs. We show that these HATs acetylate E2A in vitro, enhance E2A-mediated transcription activity, and promote nuclear retention of E2A proteins. A catalytic mutation of p300 completely abrogates the ability of p300 to acetylate E2A and to promote E2A nuclear retention in 293T cells. A breeding test between E2A heterozygous mice and p300 heterozygous mice demonstrated that these two genes interact for proper B cell development. Collectively, these results suggest that E2A and HATs collaboratively regulate B cell development."xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m211464200"xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/author | "Yoshida M."xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/author | "Komatsu Y."xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/author | "Zhuang Y."xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/author | "Yao T.P."xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/author | "Bradney C."xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/author | "Hjelmeland M."xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/pages | "2370-2376"xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/title | "Regulation of E2A activities by histone acetyltransferases in B lymphocyte development."xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12435739 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12435739 |
| http://purl.uniprot.org/citations/12435739 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12435739 |
| http://purl.uniprot.org/uniprot/Q92793#attribution-90831353B3F46D1AF8F6E20938770B4F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12435739 |
| http://purl.uniprot.org/uniprot/B2RWS6#attribution-568036E527A9E4D168E002B8B3C3B92D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12435739 |
| http://purl.uniprot.org/uniprot/Q09472#attribution-90831353B3F46D1AF8F6E20938770B4F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12435739 |
| http://purl.uniprot.org/uniprot/Q92831#attribution-90831353B3F46D1AF8F6E20938770B4F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12435739 |
| http://purl.uniprot.org/uniprot/P15923#attribution-10AB2FA19401F1A0A3EF7DEE7590242C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12435739 |
| http://purl.uniprot.org/uniprot/P15923#attribution-90831353B3F46D1AF8F6E20938770B4F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12435739 |
| http://purl.uniprot.org/uniprot/#_A0A087WPR8-mappedCitation-12435739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12435739 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNN6-mappedCitation-12435739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12435739 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J011-mappedCitation-12435739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12435739 |