| http://purl.uniprot.org/citations/12437929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12437929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12437929 | http://www.w3.org/2000/01/rdf-schema#comment | "Missense mutants that cause the immune disorder Wiskott-Aldrich Syndrome (WAS) map primarily to the Enabled/VASP homology 1 (EVH1) domain of the actin regulatory protein WASP. This domain has been implicated in both peptide and phospholipid binding. We show here that the N-WASP EVH1 domain does not bind phosphatidyl inositol-(4,5)-bisphosphate, as previously reported, but does specifically bind a 25 residue motif from the WASP Interacting Protein (WIP). The NMR structure of the complex reveals a novel recognition mechanism-the WIP ligand, which is far longer than canonical EVH1 ligands, wraps around the domain, contacting a narrow but extended surface. This recognition mechanism provides a basis for understanding the effects of mutations that cause WAS."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)01076-0"xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)01076-0"xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Lim W.A."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Lim W.A."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Scott J.A."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Scott J.A."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Peterson F.C."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Peterson F.C."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Volkman B.F."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Volkman B.F."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Prehoda K.E."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/author | "Prehoda K.E."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/pages | "565-576"xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/pages | "565-576"xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/title | "Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/title | "Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome."xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/12437929 | http://purl.uniprot.org/core/volume | "111"xsd:string |