http://purl.uniprot.org/citations/12439908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12439908 | http://www.w3.org/2000/01/rdf-schema#comment | "AimTo study the expression of early growth response gene-1 (Egr-1 gene) and Bcl-X/(L) protein and its relationship with the cell apoptosis in human esophageal carcinoma (EC) and precancerous lesions.MethodsIn situ hybridization(ISH), immunohistochemistry (IHC) and TUNEL method were used respectively to detect Egr-1mRNA, Egr-1 protein, apoptosis related-protein Bcl-X/(L) and cell apoptosis in situ from 66 cases of esophageal squamous cell carcinoma and their upper cut edge and paracancerous mucosa.ResultsEgr-1 gene in situ hybridization, Bcl-X/(L) immunohistochemistry positive products were located in the cytoplasm, while Egr-1 immunohistochemistry and TUNEL positive signal were located in the nuclei. The apoptosis index(AI) and the frequency of apoptosis occurrence were increased gradually from precancerous lesion to cancer (P<0.01) and the expression of Egr-1mRNA and Egr-1 protein in dysplasia was the highest among all specimens (P<0.01). The AI of Egr-1 positive cancer tissues was much higher than that of Egr-1 negative cancer tissues (P<0.01), while the AI of Bcl-X/(L) positive cancer tissues was much lower than that of Bcl-X/(L) negative cancer tissues (P<0.01). The AI and Egr-1 expression were not correlated with invasiveness and lymphatic metastasis in EC.ConclusionCell apoptosis was present through esophageal carcinogenesis. The expression of Egr-1 mRNA and Egr-1 protein were high in precancerous lesion of esophagus. The AI was increased significantly in Egr-1 positive squamous cell carcinoma. Egr-1 might promote apoptotic effect. Egr-1 expression and cell apoptosis may have an important biological significance in esophageal carcinogenesis."xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.org/dc/terms/identifier | "doi:10.3748/wjg.v8.i6.971"xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/author | "Wu M.Y."xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/author | "Wu X.Y."xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/author | "Zhuang C.X."xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/author | "Liang Y.R."xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/name | "World J Gastroenterol"xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/pages | "971-975"xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/title | "Relationship between Egr-1 gene expression and apoptosis in esophageal carcinoma and precancerous lesions."xsd:string |
http://purl.uniprot.org/citations/12439908 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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