| http://purl.uniprot.org/citations/12441072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12441072 | http://www.w3.org/2000/01/rdf-schema#comment | "STAT6 (signal transducers and activators of transcription 6)-deficient (STAT6-/-) mice have defects in IL-4- and IL-13-mediated functions and thus have a reduced T(H)2-mediated immune response. Conversely, they have elevated levels of IL-2 and thus an increased T(H)1-mediated immune response. To assess the relative impact of reduced T(H)2- and elevated T(H)1-dependent immune responses on HSV-1 infection, vaccinated and mock-vaccinated STAT6-/-mice were challenged ocularly with HSV-1. Mock-vaccinated STAT6-/-mice were as susceptible to lethal HSV-1 infection as parental BALB/c mice. Mock-vaccinated STAT6-/-mice had reduced HSV-1 titers in their eyes compared to BALB/c mice. Furthermore, mock-vaccinated STAT6-/-mice had significantly less corneal scarring than their BALB/c counterparts. Vaccination induced significantly higher serum-neutralizing antibody titers in STAT6-/-mice compared to BALB/c mice, while completely protecting both types of mice against HSV-1-induced death and corneal scarring. Vaccinated STAT6-/-mice had reduced HSV-1 titers in their eyes compared to BALB/c mice. Lymphocytes from both vaccinated and mock-vaccinated STAT6-/-mice secreted higher amounts of IL-2 than lymphocytes from BALB/c mice, in the presence or absence of stimulation with UV-inactivated HSV-1. Finally, depletion of IL-2 increased ocular virus replication in STAT6-/-mice to levels similar to that measured in BALB/c mice. Our results suggest that in the absence of the STAT6 pathway, IL-2-mediated immune responses are up-regulated. This, in turn, leads to faster viral clearance and, consequently, lower levels of eye disease."xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.org/dc/terms/identifier | "doi:10.1006/viro.2002.1611"xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/author | "Wechsler S.L."xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/author | "Ghiasi H."xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/author | "Nesburn A.B."xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/author | "Osorio Y."xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/pages | "286-293"xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/title | "Enhanced clearance of herpes simplex virus type 1 and reduced herpetic eye disease in STAT6 knockout mice is associated with increased IL-2."xsd:string |
| http://purl.uniprot.org/citations/12441072 | http://purl.uniprot.org/core/volume | "302"xsd:string |
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