| http://purl.uniprot.org/citations/12441142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12441142 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 7 (IL-7) is a pleiotropic cytokine which plays a role in both T and B cell function as well as in establishment and maintenance of immunological barriers in epithelial tissues. The heterodimeric IL-7 receptor (IL-7R) consists of the p76 IL-7Ralpha subunit and the p64 common gamma (gammac) subunit. Ligand-binding induces signal transduction through tyrosine phosphorylation of the janus (Jak) and src-related kinases as well as by activation of phosphatidinositol-3 kinase (P13-kinase). In an effort to further define the requirements for ligand-receptor interactions and to subsequently develop candidate receptor binding antagonists with selective biological activities, we examined a series of IL-7 mutants in which the carboxy terminal hydrophobic residues were substituted with aliphatic amino acids. In this study we describe abrogation of IL-7 driven proliferation and attenuated phosphotyrosine signaling by IL-7(143) (Trp-Ala) and IL-7(143) (Trp-His) in IL-7R expressing T and B leukemia cells. Decreased phosphorylation of Jak3 kinase by IL-7W143A, IL-7W143P and IL-7W143H suggest that alterations in this region of the carboxyterminal region of IL-7 affects its interaction with the gammac subunit of the IL-7R."xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.org/dc/terms/identifier | "doi:10.1006/cyto.2002.1974"xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/author | "Cosenza L."xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/author | "Foss F."xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/author | "Gorgun G."xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/author | "Menevse A."xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/author | "van der Spek J."xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/pages | "17-22"xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/title | "Altered biological activity associated with C-terminal modifications of IL-7."xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/12441142 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12441142 |
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